A third dose is ONLY for those who are moderately to severely immunocompromised and who received the Moderna or Pfizer vaccine as their primary vaccination series and received their second dose at least 28 days ago. The additional third shot recommendation only applies to individuals who are considered immunocompromised, as defined below.
Individuals that are considered moderately to severely immunocompromised and are recommended for a third dose include people who:
- Are undergoing active treatment for solid tumor and hematologic malignancies
- Have received a solid-organ transplant and are taking immunosuppressive therapy
- Have received CAR (chimeric antigen receptor)-T-cell or hematopoietic stem cell transplant (within 2 years of transplantation or taking immunosuppression therapy)
- Have moderate or severe primary immunodeficiency (e.g., DiGeorge, Wiskott-Aldrich syndromes)
- Have advanced or untreated HIV infection
- Are undergoing active treatment with high-dose corticosteroids (i.e., ≥20 mg prednisone or equivalent per day), alkylating agents, antimetabolites, transplant-related immunosuppressive drugs, cancer chemotherapeutic agents classified as severely immunosuppressive, TNF blockers, and other biologic agents that are immunosuppressive or immunomodulatory.
Immunocompromised individuals interested in receiving the third dose of Pfizer or Moderna should reach out to their healthcare provider or pharmacy for more information.